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Inger Helene Madshus (Epidermal Growth Factor)

Group Leader Inger Helene Madshus, Professor,  M.D., Ph.D.  

Group Members:
Espen Stang (Scientist)
Kamilla Breen (PhD student)
Ketil Winther Pedersen (Scientist)
Lene Johannessen (Postdoc)
Tram Thu Vuong (Postdoc)
Lene M. Grøvdal (PhD student)
Vibeke Bertelsen (PhD student)
Nina Marie Pedersen (PhD student
Maja Kazazic (PhD student)
Marianne Skeie Rødland (Technician)
 

The projects carried out in the group center around how EGFR family members can be downregulated physiologically and experimentally. Such studies are motivated by the fact that overexpression of these RTKs is driving oncogenesis in a number of epithelial cells. Potential ways of therapeutically downregulating these proteins is therefore of utmost importance in treatment of diseases like breast cancer, prostate cancer and glioblastomas. A prerequisite for designing mechanisms inducing therapeutic downregulation is more detailed knowledge on mechanisms normally controlling endocytosis and lysosomal degradation of the EGFR and of EGFR family members.

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