http://www.pathologyinstitute.org/cms Tue, 17 May 2011 16:20:35 +0000 http://backend.userland.com/rss092 en Head: Torill Sauer, Prof MD PhD Vera Abeler MD PhD Per Bøhler MD Ben Davidson Ass.Prof MD PhD Øystein Garred MD PhD Bjørn Risberg MD PhD   http://www.pathologyinstitute.org/cms/2011/gynecologic-and-breast-pathology/ Yuan Y, Nymoen DA, Stavnes HT, Rosnes AK, Bjørang O, Wu C, Nesland JM, Davidson B. Tenascin-X is a novel diagnostic marker of malignant mesothelioma. Am J Surg Pathol. 2009 Nov;33(11):1673-82. Tenascin-X protein expression was studied in 183 effusions (137 carcinomas of different origin, 37 mesotheliomas, and 9 reactive effusions) and 178 solid ... http://www.pathologyinstitute.org/cms/2010/davidson-s-group-present-tenascin-x-as-a-novel-diagnostic-marker-of-malignant-mesothelioma/ Madshus IH, Stang E. Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking. J Cell Sci. 2009 Oct 1;122(Pt 19):3433-9. In this Opinion article, we discuss the impact of signaling motifs, kinase activity and ubiquitylation on clathrin-dependent endocytosis and lysosomal sorting of EGFR. In addition, ... http://www.pathologyinstitute.org/cms/2010/madshus-and-stang-discuss-internalization-and-intracellular-sorting-of-the-egf-receptor/ Haraldsen G, Balogh J, Pollheimer J, Sponheim J, Küchler AM Interleukin-33 - cytokine of dual function or novel alarmin? Trends Immunol (in press) (online 7 Apr 2009) PubMed 19359217 http://www.pathologyinstitute.org/cms/2009/news-from-haraldsen%c2%b4s-group/ Küchler AM, Pollheimer J, Balogh J, Sponheim J, Manley L, Sorensen DR, De Angelis PM, Scott H, Haraldsen G. Publish in Am J Pathol. 2008 Oct;173(4):1229-42. "Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation." Interleukin (IL)-33 is a novel member of the IL-1 family of cytokines ... http://www.pathologyinstitute.org/cms/2008/haraldsen%c2%b4s-group-presents-interesting-findings-concerning-that-il-33-may-be-involved-in-the-control-of-endothelial-cell-activation/ CONCLUSIONS: A significant reduction of BUB1B level was  detected in aneuploid compared to diploid colorectal cancers,  consistent with earlier studies showing that loss of spindle checkpoint function may be involved in development of DNA aneuploidy.  Our data also show that spindle proteins are overexpressed in colorectal cancers, and that expression of the Aurora kinases is  associated with ... http://www.pathologyinstitute.org/cms/2008/clauson%c2%b4s-group-cont-publications-on-the-mechanisms-for-aneuploidy-in-colorectal-carcinoma/ Prostate: Post-treatment BM-aspirates were positive for disseminated tumor cells (DTCs) in 17% of cases without correlation to any of the tested variables. Out of 14 patients who had DTCs in BM prior to treatment, all but one had become post-treatment negative. Out of 95 patients with pre-treatment negative BM status, 18 (19%) had become post-treatment  positive. ... http://www.pathologyinstitute.org/cms/2008/the-micrometastasis-project-group-publish-results-in-breast-and-prostate-cancer-patients/ Conclusion: Our study showed that T cells from grass pollen-allergic  patients and non-atopic controls responded very differently to grass pollen extract, but this difference could not be explained by differences in regulatory T cell function. Further studies are needed  to understand the importance of regulatory T cells in allergy. Published in Clin Exp Allergy. 2008 Jul ... http://www.pathologyinstitute.org/cms/2008/jahnsen-group-publish-depletion-of-cd4cd25cd127lo-regulatory-t-cells-does-not-increase-allergen-driven-t-cell-activation/ Kleinberg L, Holth A, Trope CG, Reich R, Davidson B. Claudin upregulation in ovarian carcinoma effusions is associated with poor survival. Hum Pathol. 2008 May;39(5):747-57. Davidson B,  Wang TL, Shih IeM, Berner A Expression of the chromatin remodeling factor Rsf-1 is down-regulated in breast carcinoma effusions.  Hum Pathol. 2008 Apr;39(4):616-22. Epub 2008 Mar 4  Davidson B, Hadar R, ... http://www.pathologyinstitute.org/cms/2008/new-papers-from-davidson%c2%b4s-group-on-claudin-rsf-1-dj-1-and-death-receptors-in-ovarian-and-breast-cancer/ Our study showed that removal of CD25+ T(regs) enhanced anti-tumour  immunity against local growth of a B cell lymphoma and that induction or expansion of T(regs) could be one mechanism by which the growing tumour evades immune surveillance. Published in Clin Exp Immunol. 2008 May;152(2):381-7. Epub 2008 Mar 12. Link Depletion of CD4+ CD25+ regulatory ... http://www.pathologyinstitute.org/cms/2008/the-liipat-and-jahnsen-group-depletion-of-cd4-cd25-regulatory-t-cells-inhibits-local-tumour-growth-in-a-mouse-model-of-b-cell-lymphoma/ In conclusion, H-Ras and K-Ras  had differential functions in proliferation and survival of primary  hepatocytes. H-Ras was the major mediator of ERK-induced proliferation  and survival, whereas H-Ras and K-Ras both mediated PI3K-induced survival. Distinct functions of H-Ras and K-Ras in proliferation and survival of  primary hepatocytes due to selective activation of ERK and PI3K. Rosseland CM, ... http://www.pathologyinstitute.org/cms/2008/huitfeldts-group-found-distinct-functions-of-h-ras-and-k-ras-in-proliferation-and-survival-of-due-to-selective-activation-of-erk-and-pi3k/  In both models we observed a significant reduction of  EGFR expression at the protein but not mRNA level. CONCLUSION: Our results suggest that PKA may represent a target  that when manipulated can maintain EGFR protein levels at the single cell level as well as in intact animals. Published in BMC Cell Biol. 2008 Apr 1;9:16.  ... http://www.pathologyinstitute.org/cms/2008/huitfeldts-group-found-epidermal-growth-factor-receptor-levels-are-reduced-in-mice-with-targeted-disruption-of-the-protein-kinase-a-catalytic-subunit/ This review by Grandal MV and  Madshus IH focuses on mechanisms involved in ligand-induced EGFR  activation and endocytic down-regulation. A better understanding of EGFR biology should allow development of more tumor-selective therapeutic approaches targeting EGFR-induced signalling. Published in J Cell Mol Med. 2008 Mar 4. [Epub ahead of print] Link http://www.pathologyinstitute.org/cms/2008/review-focuses-on-mechanisms-involved-in-ligand-induced-egfr-by-madshus-ih/ Ben Davidson´s group publish a Methods for simultaneous measurement of apoptosis and cell surface phenotype of epithelial cells in effusions by flow cytometry in Nat Protoc. 2008;3(6):955-64. Dong HP, Kleinberg L, Davidson B, Risberg B. Division of Pathology, Norwegian Radium Hospital, Rikshospitalet Medical Center, Ullernchaussen 70, Montebello, N-0310 Oslo, Norway. We describe here a ... http://www.pathologyinstitute.org/cms/2008/ben-davidson%c2%b4s-group-publish-a-methods-for-measurement-of-apoptosis-in-nature-protocols/ Heier I, Hofgaard PO, Brandtaeg P, Jahnsen FL, Karlsson M. . Links Depletion of CD4+ CD25+ regulatory T cells inhibits local tumour growth in a mouse model of B cell lymphoma. Clin Exp Immunol. 2008 May;152(2):381-7. Epub 2008 Mar Regulatory T cells (T(regs)) may inhibit immunity against cancer.  Induction and expansion of T(regs) in the immunosuppressive microenvironment created ... http://www.pathologyinstitute.org/cms/2008/liipat-group-news-regulatory-t-cells-tregs-may-inhibit-immunity-against-cancer/ Holt PG, Strickland DH, Wikström ME, Jahnsen FL. Regulation of immunological homeostasis in the respiratory tract. Nat Rev Immunol. 2008 Feb;8(2):142-52. Links Telethon Institute for Child Health Research, Centre for Child Health  Research, The University of Western Australia, Perth 6009, Western Australia. patrick@ichr.uwa.edu.au The respiratory tract has an approximate surface area of 70 m2 in adult humans, ... http://www.pathologyinstitute.org/cms/2008/f-jahnsen-together-with-an-australian-group-publish-a-paper-in-nature-review-immunology/ Heier I, Malmström K, Pelkonen AS, Malmberg SP, Kajosaari M, Turpeinen M, Lindahl H, Brandtzaeg P, Jahnsen FL, Mäkelä MJ. Bronchial response pattern of antigen presenting cells and regulatory T cells in children below two years of age. Thorax. 2008 Feb 4. [Epub ahead of print] A well-developed HLA-DR+ network of antigen presenting cells  was present in ... http://www.pathologyinstitute.org/cms/2008/liipat-group-found-that-lymphoid-follicles-play-an-important-role-in-bronchial-immune-homeostasis-during-infancy/ Kleinberg L, Holth A, Trope CG, Reich R, Davidson B. Claudin upregulation in ovarian carcinoma effusions is associated with poor survival. Hum Pathol. 2008 May;39(5):747-57. Davidson B,  Wang TL, Shih IeM, Berner A Expression of the chromatin remodeling factor Rsf-1 is down-regulated in breast carcinoma effusions.  Hum Pathol. 2008 Apr;39(4):616-22. Epub 2008 Mar 4  Davidson B, Hadar R, ... http://www.pathologyinstitute.org/cms/2008/new-papers-from-davidson%c2%b4s-group-on-caludin-rsf-1-dj-1-and-death-receptors-in-ovarian-cancer/ Breland UM, Halvorsen B, Hol J, Oie E, Paulsson-Berne G, Yndestad A, Smith C, Otterdal K, Hedin U, Waehre T, SandbergWJ, Froland SS, Haraldsen G, Gullestad L, Damas JK, Hansson GK, Aukrust P. A Potential Role of the CXC Chemokine GROα in Atherosclerosis and Plaque Destabilization. Downregulatory Effects of Statins. ... http://www.pathologyinstitute.org/cms/2008/new-paper-on-statins-and-chemokines/ Skarpen E, Flinder LI, Rosseland CM, Orstavik S, Wierød L, Oksvold MP, Skålhegg BS, Huitfeldt HS.MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments.FASEB J. 2008 Feb;22(2):466-76. Epub 2007 Oct 10. Huitfeldts group propose that the requirement of adhesion for cells to proliferate in response ... http://www.pathologyinstitute.org/cms/2008/mek1-and-mek2-regulate-distinct-functions-by-sorting-erk2-to-different-intracellular-from-huitfeldts-group/