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Inger Helene Madshus, Professor, MD, PhD.

Professor
Institute of Pathology

Division of Pathology
Rikshospitalet
0027 Oslo
Norway

Office: + (47) 2307
Fax: + (47)
email: inger.helene.madshus@rikshospitalet.no


Training:

Expertise:

Research Interests:
How EGFR family members can be downregulated physiologically and experimentally

Professional Service:

Other Links:


Selected Publications:

Grandal MV, Madshus IH.
Epidermal Growth Factor Receptor and Cancer:
Control of Oncogenic Signalling by Endocytosis.
J Cell Mol Med. 2008 Mar 4

Grøvdal LM, Johannessen LE, Rødland MS, Madshus IH, Stang E.
Dysregulation of Ack1 inhibits down-regulation of the EGF receptor.
Exp Cell Res. 2008 Apr 1;314(6):1292-1300. Epub 2008 Jan 5.

Bertelsen V, Breen K, Sandvig K, Stang E, Madshus IH.
The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.
Exp Cell Res. 2007 May 1;313(8):1696-709. Epub 2007 Feb 28.

Kazazic M, Roepstorff K, Johannessen LE, Pedersen NM, van Deurs B, Stang E, Madshus IH.
EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae.
Traffic. 2006 Nov;7(11):1518-27. Epub 2006 Sep 19.

Haslekås C, Breen K, Pedersen KW, Johannessen LE, Stang E, Madshus IH.
The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane.
Mol Biol Cell. 2005 Dec;16(12):5832-42. Epub 2005 Oct 5.

Longva KE, Pedersen NM, Haslekås C, Stang E, Madshus IH.
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not
endocytic down-regulation of ErbB2.
Int J Cancer. 2005 Sep 1;116(3):359-67.

Grøvdal LM, Stang E, Sorkin A, Madshus IH.
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.
Exp Cell Res. 2004 Nov 1;300(2):388-95.

Stang E, Blystad FD, Kazazic M, Bertelsen V, Brodahl T, Raiborg C, Stenmark H, Madshus IH.
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits.
Mol Biol Cell. 2004 Aug;15(8):3591-604. Epub 2004 Jun 11.

Normann AP, Egeland T, Madshus IH, Heim S, Tjønnfjord GE.
CD7 expression by CD34+ cells in CML patients, of prognostic significance?
Eur J Haematol. 2003 Oct;71(4):266-75.