CONCLUSIONS:
A significant reduction of BUB1B level was
 detected in aneuploid compared to diploid colorectal cancers,
 consistent with earlier studies showing that loss of spindle
checkpoint function may be involved in development of DNA aneuploidy.
 Our data also show that spindle proteins are overexpressed in
colorectal cancers, and that expression of the Aurora kinases is
 associated with prognosis in colorectal cancer.

Cell Prolif. 2008 Aug;41(4):645-59. Links
Reduced level of the spindle checkpoint protein BUB1B is associated
with aneuploidy in colorectal cancers.Burum-Auensen E, DeAngelis PM,
Schjølberg AR, Røislien J, Mjåland O, Clausen OP. LINK

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Prostate:
Post-treatment BM-aspirates were positive
for disseminated tumor cells (DTCs) in 17% of cases without correlation to any of the tested
variables. Out of 14 patients who had DTCs in BM prior to treatment,
all but one had become post-treatment negative. Out of 95 patients
with pre-treatment negative BM status, 18 (19%) had become post-treatment
 positive. CONCLUSIONS: DTCs in BM were found in 17% of clinically
progression-free PC patients following RT. The detection of these
cells may provide PSA-independent prognostic information remaining
to be explored by prolonged follow-up.
Prostate. 2008 Jul 24. [Epub ahead of print] Link
Disseminated tumor cells in bone marrow following definitive radiotherapy
for intermediate or high-risk prostate cancer.Berg A, Bruland OS, Fosså SD,
 Nesland JM, Berner A, Schirmer C, Lilleby W.LINK

Breast:
High vascular grades
determined by Chalkley counts were significantly associated with shorter
 distant disease-free survival and breast cancer-specific survival in all
 patients (P < 0.001, log-rank) and in node-negative patients not
receiving adjuvant systemic therapy (P < 0.05). In multivariate analysis,
 both CD34 and CD105 Chalkley counts showed prognostic significance for
 distant disease-free survival (P = 0.014 and P = 0.026), whereas CD34
 also showed prognostic significance for breast cancer-specific survival
 (P = 0.007). Vascular invasion and DTCs in the bone marrow showed
independent prognostic significance. DTC did not discriminate survival
 for CD34 low Chalkley counts, whereas a very poor prognosis was observed
 for DTC-positive patients with high CD34 counts. In node-negative patients
 not receiving systemic chemotherapy, high CD34 and high CD105 counts in
combination identified patients with unfavorable outcome, as opposed to
all other CD34/CD105 combinations. CONCLUSIONS: Improved identification
of risk groups could be obtained by adding CD34 and CD105 vascular analysis
 to DTC, vascular invasion, and other primary tumor factors. This may
 facilitate the selection of candidates for adjuvant systemic therapy.
Clin Cancer Res. 2008 Apr 15;14(8):2341-50. Links
Vascularization in primary breast carcinomas: its prognostic significance
 and relationship with tumor cell dissemination.Dhakal HP, Naume B,
Synnestvedt M, Borgen E, Kaaresen R, Schlichting E, Wiedswang G,
Bassarova A, Giercksky KE, Nesland JM. LINK

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Conclusion:
Our study showed that T cells from grass pollen-allergic
 patients and non-atopic controls responded very differently to
grass pollen extract, but this difference could not be explained by
differences in regulatory T cell function. Further studies are needed
 to understand the importance of regulatory T cells in allergy.

Published in Clin Exp Allergy. 2008 Jul 31.
Depletion of CD4(+)CD25(+)CD127(lo) regulatory T cells does not
 increase allergen-driven T cell activation.Skrindo I, Farkas L,
Kvale EO, Johansen FE, Jahnsen FL. Link
 

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Kleinberg L, Holth A, Trope CG, Reich R, Davidson B.
Claudin upregulation in ovarian carcinoma effusions is associated
with poor survival.
Hum Pathol. 2008 May;39(5):747-57.

Davidson B,  Wang TL, Shih IeM, Berner A
Expression of the chromatin remodeling factor Rsf-1 is down-regulated in breast carcinoma effusions.
 Hum Pathol. 2008 Apr;39(4):616-22. Epub 2008 Mar 4

 Davidson B, Hadar R, Schlossberg A, Sternlicht T,
 Slipicevic A, Skrede M, Risberg B, Flørenes VA, Kopolovic J, Reich R.
Expression and clinical role of DJ-1, a negative regulator of PTEN,
in ovarian carcinoma.
Hum Pathol. 2008 Jan;39(1):87-95. Epub 2007 Oct 18. Links

Dong HP, Kleinberg L, Silins I, Flørenes VA, Tropé CG, Risberg B,
Nesland JM, Davidson B.Davidson B
 Death receptor expression is associated with poor response to
 chemotherapy and shorter survival in metastatic ovarian carcinoma.
Cancer. 2008 Jan 1;112(1):84-93.

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Our study showed that removal of CD25+ T(regs) enhanced anti-tumour
 immunity against local growth of a B cell lymphoma and that
induction or expansion of T(regs) could be one mechanism by
which the growing tumour evades immune surveillance.
Published in Clin Exp Immunol. 2008 May;152(2):381-7. Epub 2008 Mar 12. Link
Depletion of CD4+ CD25+ regulatory T cells inhibits local tumour
growth in a mouse model of B cell lymphoma.Heier I, Hofgaard PO,
Brandtzaeg P, Jahnsen FL, Karlsson M. 

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In conclusion, H-Ras and K-Ras
 had differential functions in proliferation and survival of primary
 hepatocytes. H-Ras was the major mediator of ERK-induced proliferation
 and survival, whereas H-Ras and K-Ras both mediated PI3K-induced survival.

Distinct functions of H-Ras and K-Ras in proliferation and survival of
 primary hepatocytes due to selective activation of ERK and PI3K.
Rosseland CM, Wierød L, Flinder LI, Oksvold MP, Skarpen E, Huitfeldt HS.
Laboratory for Toxicopathology, Institute of Pathology,
 Rikshospitalet-Radiumhospitalet Medical Centre,
University of Oslo, Norway. carola.rosseland@labmed.uio.no
Published in J Cell Physiol. 2008 Jun;215(3):818-26. Link 

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 In both models we observed a significant reduction of
 EGFR expression at the protein but not mRNA level.
CONCLUSION: Our results suggest that PKA may represent a target
 that when manipulated can maintain EGFR protein levels at the
single cell level as well as in intact animals.

Published in BMC Cell Biol. 2008 Apr 1;9:16.  Link

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This review by Grandal MV and  Madshus IH focuses on mechanisms involved in ligand-induced EGFR  activation and endocytic down-regulation. A better understanding of EGFR biology should allow development of more tumor-selective
therapeutic approaches targeting EGFR-induced signalling.

Published in J Cell Mol Med. 2008 Mar 4. [Epub ahead of print] Link

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