MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments -from Huitfeldts group
Skarpen E, Flinder LI, Rosseland CM, Orstavik S, Wierød L, Oksvold MP, Skålhegg BS, Huitfeldt
HS.MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular
compartments.FASEB J. 2008 Feb;22(2):466-76. Epub 2007 Oct 10.
Huitfeldts group propose that the requirement of adhesion for cells to proliferate in response to growth
factors, in part, may be explained by the MEK1 S298/T292 control of ERK2 nuclear translocation.
In addition, we suggest that ERK2 intracellular localization determines whether growth factors
mediate proliferation or survival and that the sorting occurs in an adhesion-dependent manner.