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Our Laboratory for Toxicopathology; Latest publication in Oncogene concerning EGF and p53 function

Posted on December 29th, 2007 by Björn Risberg

L Wierød et al :Activation of the p53–p21Cip1 pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes 
Oncogene. 2007 Nov 19 [Epub ahead of print]
Here we show that epidermal growth factor (EGF) activated p53 in a phosphatidylinositol-3 kinase-dependent way, and thus induced the cyclin-dependent kinase inhibitor p21(Cip1) in primary rat hepatocytes.

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